![]() Nearly 60% of manufacturers are reporting resin shortages. Repercussions of Hurricane Laura in 2020 and Winter Storm Uri in February 2021 hit the Resin/Plastic industry hard.The manufacturers cannot keep up with demand. The supply issue is due to a global shortage of a Resin material the cups are made from, and staff shortages.Some collection sites may not have collection cups, or they have low supplies. They expect this to continue for the next 12 months. Quest Diagnostics (all areas) and collection sites are still experiencing staff shortages.(example: if the courier picks up specimens at noon, anything collected after that will not be picked up by the courier until the next day, weekends could be a definite challenge).Now it will be once per day, due to staff shortages. Courier pick-up Fed Ex or Quest Diagnostics Couriers used to pick up specimens multiple times a day.Positive results are taking about 5-7 days.Negative results are returning within 24 hours after the collection.We have contacted Quest Diagnostics regarding delays in drug testing results and would like to pass along some important information for Drug Screening in 2022. Search America ® National Criminal Database.A clinician’s test selection and interpretation, diagnosis, and patient management decisions should be based on his/her education, clinical expertise, and assessment of the patient. This FAQ is provided for informational purposes only and is not intended as medical advice. Harmonization of infliximab and anti-infliximab assays facilitates the comparison between originators and biosimilars in clinical samples. Gils A, Van Stappen T, Dreesen E, et al.United States Food and Drug Administration Biosimilar Guidance webpage.Comparison of techniques for monitoring infliximab and antibodies against infliximab in Crohn’s disease. Steenholdt C, Ainsworth MA, Tovey M, et al.Immunogenicity of anti-TNF-α biotherapies, I: individualized medicine based on immunopharmacological evidence. Immunogenicity assessment of tumor necrosis factor antagonists in the clinical laboratory. Comparative immunogenicity of TNF inhibitors: impact on clinical efficacy and tolerability in the management of autoimmune diseases: a systematic review and meta-analysis. Thomas SS, Borazan N, Barroso N, et al.Assessing response and loss of response to biological therapies in IBD. ![]() Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: definitions, frequency and pharmacological aspects. Efficacy of biological therapies in inflammatory bowel disease: systematic review and meta-analysis. American Gastroenterological Association Institute Guideline on therapeutic drug monitoring in inflammatory bowel disease. Feuerstein JD, Nguyen GC, Kupfer SS, et al.Guidelines of care for the management of psoriasis and psoriatic arthritis, section 1: overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics. Menter A, Gottlieb A, Feldman SR, et al.2015 American College of Rheumatology guideline for the treatment of rheumatoid arthritis. Singh JA, Saag KG, Bridges SL Jr, et al.9 Development of anti-drug antibodies reduced the odds of clinical response by 67% overall, although nearly half of the data were derived from articles involving infliximab or adalimumab. In that study, anti-drug antibodies were detected more often in patients treated with infliximab (25%) than in those treated adalimumab (14%), certolizumab (6.9%), golimumab (3.8%), or etanercept (1.2%). The immunogenicity of TNF-alpha inhibitors (adalimumab, infliximab, etanercept, golimumab, and certolizumab) was investigated in a meta-analysis of 68 studies (14,651 patients) performed from 1966 to 2013. In patients with secondary failure, subtherapeutic drug levels may also be caused by the development of anti-drug antibodies that is, antibodies that target and lower the bioavailability of TNF-alpha inhibitors. In patients with primary treatment failure, subtherapeutic levels may indicate poor adherence or increased drug clearance, or other pharmacokinetic issues. Several factors can predispose to primary and secondary treatment failure.
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